ZOGRAF 1 mg helps in preventing the rejection of transplanted organs by recipient immune system

The individual requires the transplantation of the organ under the condition of its failure. This takes place either due to some kind of illness or accident. When an individual undergoes an organ transplant, there is the removal of the organ from the body of another individual and then transplanting into the recipient’s body. However, one of the important risks involved is the rejection of the transplant by the recipient’s body. This takes place whenever the immune system of the patient attacks the transplanted organ. So if the patient undergoes a transplant, they are required to take the immunosuppressant drug in order to keep the immune system of the body to reject the new organ.

The immunosuppressants are administered for the prevention of the rejection of the organ, while at the same time reversing most acute rejection while transplanting the organ. Tacrolimus is acting as the immunosuppressant meant for the inhibition of the rejection of solid organ transplantation. This is working through the prevention of the rejection through the inhibition of the lymphocyte cells(specifically T cells), present in the immune system.

Description about ZOGRAF 1 mg

ZOGRAF 1 mg is a prescription medication that is administered in combination with other drugs for individuals who are having cardiac, kidney, liver, or lung transplantation. The drug is acting by weakening the patient’s immune system, thereby preventing the body from rejection of the transplanted organ. So it is acting by lowering down the natural immune system of the body. This type of the responsiveness of immune system is being associated with Nephrotic Syndrome. So it is meant for the prevention of the rejection of an organ that is transplanted to the recipient’s body.

Composition of ZOGRAF 1 mg

The main substance which is existing in ZOGRAF 1 mg is Tacrolimus

Uses of ZOGRAF 1 mg

The main purpose for which ZOGRAF 1 mg is administered in combination with other drugs includes the prevention of the rejection of transplanted organs. It is acting as an immunosuppressive agent, carrying out the weakening of the immune system for the acceptance of the new organ. Also, the medicine is administered for the treatment of Eczema in patients who have not given positive responses with other drugs.

How Tacrolimus is working?

Since, ZOGRAF is containing Tacrolimus, an immunosuppressant and thus, it is working through the suppression of the immune responsiveness of the body system, so that it is capable of accepting the new transplanted organ as if it is its own.

Dosage of ZOGRAF 1 mg

The ZOGRAF 1 mg dosage is dependent upon the patient’s body weight, physical condition, outcome of blood diagnostic as well as the responsiveness towards the therapeutic process. Never increase or reduce the dosage of the medicine without the approval of the physician. Also, consume the drug on a regular basis and during the same time of the day.

How ZOGRAF 1 mg is administered?

This medication is administered by the doctor. This is done after a careful evaluation of the patient’s condition. Don’t stop or alter the medicinal dosage on your own without the consultation of a doctor. Make sure to take the medicine during the same time of the day. And you can consume it towards the same time, with your meal or without your meal. Also do not cut, crush or chew your tablet.

Possible side effects of taking ZOGRAF 1 mg

There might be some undesirable effects while you are administered Tacrolimus. Check with the doctor in case you have these undesirable effects and they don’t go away at all:

• Trouble while sleeping
• Diarrhea
• Nausea
• Vomiting
• Pain in abdomen
• Energy loss
• General weakness
• Frequent urination
• Twitching in muscles
• Alteration in mood
• Numbness
• Tingling
• Rashes in skin
• Headache
• Infections

There can be other problems that may arise, call your doctor straight away if any undesirable effect does not go away

Drug interactions

Here are some of the medications, and using them with ZOGRAF 1 mg produces harmful side effects.  The physician may decide not to treat you with this medication while you are already on this immunosuppressant.

• Bepridil
• Cisapride
• Dronedarone
• Fluconazole
• Lefamulin
• Mesoridazine
• Nelfinavir
• Pimozide
• Piperaquine
• Ritonavir
• Saquinavir
• Sparfloxacin
• Terfenadine
• Thioridazine
• Ziprasidone

Food interactions

Avoid consuming grapefruit juice/wine while being on the drug treatment as it increases the chances of the adverse impacts of taking this drug

General Warning & Precautions

• ZOGRAF tends to weaken the immune system of the body. So, the body becomes more prone to infection. Make sure to closely look for the infection symptoms. This includes chills, cough, and soaring of the throat. Get in touch with the physician if the infectious system doesn’t go away
• Make sure not to take immunization without the consent of a doctor
• The intake of Tacrolimus makes the body susceptible to skin cancers. Ensure to provide coverage to the skin while you are going outside. Also, put sunscreen with high SPF for preventing sunburn
• The ZOGRAF 1 mg & other medications may alter the level of the blood within the body. Check with the physician before you are taking the prescription/ herbal/ non-prescription products.
• Make sure not to consume grapefruit juice/ grapefruit wine while you are taking Tacrolimus. This increases the blood level within the body and makes it more prone to harmful effects
• Make sure not to take the antacids as it decreases the rate of the absorption of Tacrolimus. Also, ensure and be extra careful if you are diabetic as the medication may increase the level of blood sugar
• There might be the possibility of reducing the proper functioning of kidney organs due to the elevation in the blood level while taking Tacrolimus. So visit your doctor regularly so that they can frequently check the blood for making the proper adjustment of the drug dosage.

Where to keep Tacrolimus?

While storing the medicinal bottle, keep it in a closed almirah, and the temperature of the room should be optimum. Never store the bottle of medicine in the bathroom or any place where there is dampness.  However, if there are any unused or expired medicines, discard them properly.

FAQs(Frequently Asked Questions)

• For how long duration ZOGRAF 1 mg needs to be taken?

If the doctor is treating you with ZOGRAF 1 mg, then generally it is expected to take for the rest of your life for preventing the transplanted organ rejection. The doctor best decides the course of the treatment after evaluation of your condition.

• Can ZOGRAF 1 mg lead to hair loss?

This is not common. However, some of the patients who have been treated with ZOGRAF noticed the loss of their hair within a few months. Although, it does not take place for everyone. However, if you are concerned about your hair loss, communicate with your health care provider.