Pazosure 400

What is Pazosure 400?

Pazosure 400 is a prescription medication that contains Pazopanib Hydrochloride 400 mg, an oral tyrosine kinase inhibitor (TKI). It is primarily used in the treatment of certain types of cancer, including advanced renal cell carcinoma (RCC) and soft tissue sarcoma. It works by blocking cancer cell growth and slowing disease progression.

What are the Uses of Pazosure 400?

Pazosure 400 is used in the treatment of:

• Advanced renal cell carcinoma (kidney cancer)

• Advanced soft tissue sarcoma (especially after chemotherapy failure)

• Off-label: May be used for other cancers based on oncologist’s discretion

What are the Benefits of Pazosure 400?

• Slows tumor growth

• Improves progression-free survival in cancer patients

• Targets specific cancer pathways with minimal effects on normal cells

• Oral administration—no need for hospital infusions

How Does Pazosure 400 Work?

Pazosure (Pazopanib) is a multi-targeted tyrosine kinase inhibitor that:

• Blocks VEGFR, PDGFR, and c-Kit receptors

• Inhibits angiogenesis (formation of new blood vessels in tumors)

• Starves the tumor of nutrients and oxygen

• Slows or halts the progression of cancer

How to Take Pazosure 400?

• Take once daily, on an empty stomach (1 hour before or 2 hours after meals)

• Swallow the tablet whole with water

• Take at the same time each day

Dosage of Pazosure 400

• Standard adult dose: 400 mg to 800 mg once daily, depending on cancer type and tolerance.

• The dose may be adjusted based on response and side effects.

• Always follow the oncologist’s instructions.

Missed Dose and Overdose

Missed Dose:

• Take as soon as remembered, unless it’s close to the next dose.

• Do not double dose.

Overdose:

• Can lead to severe liver damage, high blood pressure, or heart problems

• Seek immediate medical help

What are the Available Strengths of Pazosure?

Pazosure is typically available in:

• Pazosure 400 mg tablets

Other generic brands of Pazopanib may also be available in:

• 200 mg or 400 mg strengths

Side Effects of Pazosure 400

Common side effects:

• Fatigue

• Diarrhea

• Loss of appetite

• Weight loss

• Hair color changes

Serious side effects:

• Liver damage (monitor liver enzymes)

• Hypertension

• Heart problems (QT prolongation, heart failure)

• Thrombotic events

• Bleeding or GI perforation

Interactions of Pazosure 400

May interact with:

• CYP3A4 inhibitors/inducers (like ketoconazole, rifampicin)

• Heart medications

• Warfarin and other blood thinners

• Certain antibiotics and antifungals

• Grapefruit juice (can increase drug levels)

Always inform your doctor about all drugs and supplements you’re taking.

Precautions of Pazosure 400

• Regular liver function tests required

• Monitor blood pressure routinely

• Use contraception during treatment and 2 weeks after stopping

• Not recommended in pregnancy or breastfeeding

• Caution in patients with heart disease or bleeding disorders

Storage Information

• Store at room temperature (15–30°C)

• Protect from moisture and heat

• Keep away from children and pets

Availability in the US and AUS

• USA: Pazopanib is approved under the brand name Votrient (by Novartis). Pazosure may not be available unless imported.

• Australia: Approved under Votrient. Pazosure is not a registered brand; generic pazopanib may be accessed via special access schemes.

Frequently Asked Questions (FAQs)

1. Is Pazosure 400 a chemotherapy drug?

No, it is a targeted therapy, not traditional chemotherapy.

2. How long can I take Pazosure 400?

Duration depends on your cancer type, response, and tolerability—monitored closely by your oncologist.

3. Can Pazosure cause hair loss?

Not typical hair loss, but hair color changes may occur.

4. Is it safe with food?

No. It must be taken on an empty stomach.

5. What if I vomit after taking Pazosure?

Do not retake the dose. Consult your doctor.

Insight from Gleason Healthcare Medical Experts

Founded in 2012, Gleason Health Care has rapidly emerged as one of India’s leading pharmaceutical companies, specializing in the manufacturing and marketing of generic medications, hormonal therapies, nutraceuticals, and related healthcare products. Quality, innovation, and customer-centric service form the cornerstone of Gleason Health Care’s operational philosophy. The company embraces a technology-driven approach to meet the evolving demands of emerging markets and to drive sustainable growth.