Palsure 125

What is Palsure 125?

Palsure 125 is a prescription antifungal medication that contains Posaconazole 125 mg, a broad-spectrum triazole antifungal. It is commonly used in the prevention and treatment of serious fungal infections, especially in immunocompromised patients.

What are the Uses of Palsure 125?

Palsure 125 is used for:

• Prophylaxis of invasive fungal infections in high-risk patients (e.g., after chemotherapy or organ transplant)

• Treatment of oropharyngeal candidiasis (fungal infections in the mouth and throat)

• Rescue therapy for fungal infections that are refractory or intolerant to other antifungals

• Treatment of mucormycosis (rare but aggressive fungal infection)

What are the Benefits of Palsure 125?

• Effective against a wide range of fungal pathogens

• Suitable for both preventive and curative treatment

• Useful in patients with resistance or intolerance to other antifungal drugs

• Oral administration is convenient for long-term outpatient therapy

How Does Palsure 125 Work?

Palsure 125 (Posaconazole) works by inhibiting the fungal enzyme lanosterol 14-alpha-demethylase, crucial for the synthesis of ergosterol, a key component of fungal cell membranes. Inhibition disrupts cell membrane integrity, leading to fungal cell death.

How to Take Palsure 125?

• Take exactly as prescribed by your physician.

• It is best taken with a full meal or nutritional supplement to enhance absorption.

• Swallow tablets whole with water; do not crush or chew.

• Maintain regular dosing intervals for optimal results.

Dosage of Palsure 125

Typical dosage guidelines (may vary by case):

• Loading dose: 300 mg twice on the first day

• Maintenance dose: 125 mg to 300 mg once daily, depending on infection type and severity

Always follow your doctor’s exact dosage instructions.

Missed Dose and Overdose

• Missed dose: Take it as soon as possible. If it’s close to the next dose, skip the missed one. Do not double dose.

• Overdose: May result in nausea, vomiting, elevated liver enzymes, or cardiac issues. Seek immediate medical help if overdose is suspected.

What are the Available Strengths of Palsure?

• Palsure 125 mg

• Palsure 200 mg

• May also be available in other dosage forms like:

  • Posaconazole oral suspension

  • Intravenous formulation (for hospital use)

Side Effects of Palsure 125

Common side effects:

• Nausea

• Vomiting

• Diarrhea

• Headache

• Fatigue

Serious side effects:

• Liver function abnormalities (elevated ALT/AST)

• QT prolongation (heart rhythm changes)

• Hypokalemia or hypomagnesemia (electrolyte imbalances)

• Hypersensitivity or allergic reactions

Interactions of Palsure 125

Palsure 125 may interact with:

• Rifampin

• Phenytoin

• Carbamazepine

• Cyclosporine and tacrolimus

• Statins

• Proton pump inhibitors (PPIs)

Always share your complete medication list with your doctor.

Precautions of Palsure 125

• Use with caution in patients with liver disease

• Avoid use in patients with known hypersensitivity to Posaconazole

• Regular monitoring of liver enzymes and electrolytes

• Caution advised in patients with cardiac conduction disorders

• Not recommended in pregnancy or breastfeeding unless absolutely necessary

Storage Information

• Store at room temperature (15–30°C or 59–86°F)

• Keep away from moisture, heat, and direct sunlight

• Store in original packaging and keep out of reach of children

Availability in the US and Australia

• US: Posaconazole is widely available under the brand Noxafil. Palsure 125 may not be sold under this specific name but may be available as a generic or imported equivalent.

• Australia: Posaconazole is available under prescription, mainly through hospital pharmacies or special access schemes.

Frequently Asked Questions (FAQ)

Q1. Is Palsure 125 suitable for children?

It is primarily prescribed for adults; pediatric use is possible under specialist supervision.

Q2. Can I take Palsure 125 with antacids or PPIs?

It’s best to avoid these as they can reduce absorption. Consult your doctor.

Q3. How long does it take for Palsure 125 to work?

Improvement may be noticed within a few days, but full treatment duration must be completed as prescribed.

Q4. Is liver monitoring required during treatment?

Yes, liver function should be monitored periodically during long-term use.

Q5. Can I drink alcohol during therapy?

Avoid alcohol as it can increase the risk of liver damage.

Insight from Gleason Healthcare Medical Experts

Founded in 2012, Gleason Health Care has rapidly emerged as one of India’s leading pharmaceutical companies, specializing in the manufacturing and marketing of generic medications, hormonal therapies, nutraceuticals, and related healthcare products. Quality, innovation, and customer-centric service form the cornerstone of Gleason Health Care’s operational philosophy. The company embraces a technology-driven approach to meet the evolving demands of emerging markets and to drive sustainable growth.